HPV- induced local epithelial hyperplasia.

ETIOLOGY

Caused by HPV-B and HPV-32

CLINICAL FEATURES

SEX- no gender prediliction

AGE- Children

SITE- labial, lingual, buccal mucosa.

clinical presentation

• LESION-
  • Papular in nature
  • broad based
  • same colour as skin-pale/white.

• 0.3-1 cm, discrete ,well demarcated plaques
• smooth surfaced/flat topped are commonly seen.
• they cluster closely together that they give COBBLE STONE/FISSURED APPEARANCE.

HISTOLOGIC FEATURES

• ACANTHOSIS of oral epithelium.
• RETE RIDGE FORMATION
  • normal
  • but are indented, confluent and club-shaped

• MITOSOID CELL
  • Result from viral alteration of the cells.

• PAPPILARY PROJECTIONS.

TREATMENT

• Conservative excisional biopsy.
• Spontaneous regression is observed.