FOCAL EPITHELIAL HYPERPLASIA(HECK DISEASE)

HPV- induced local epithelial hyperplasia.

ETIOLOGY

Caused by HPV-B and HPV-32

CLINICAL FEATURES

SEX- no gender prediliction

AGE- Children

SITE- labial, lingual, buccal mucosa.

clinical presentation

  • LESION-
    • Papular in nature
    • broad based
    • same colour as skin-pale/white.
  • 0.3-1 cm, discrete ,well demarcated plaques
  • smooth surfaced/flat topped are commonly seen.
  • they cluster closely together that they give COBBLE STONE/FISSURED APPEARANCE.

HISTOLOGIC FEATURES

  • ACANTHOSIS of oral epithelium.
  • RETE RIDGE FORMATION
    • normal
    • but are indented, confluent and club-shaped
  • MITOSOID CELL
    • Result from viral alteration of the cells.
  • PAPPILARY PROJECTIONS.

TREATMENT

  • Conservative excisional biopsy.
  • Spontaneous regression is observed.

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