Heparin

HEPARIN

  • MOA:  binds to antithrombin III thereby potentiating inactivation of thrombin and factors IX, Xa, XI, XII; prevents fibrinogen → fibrin; preferential inactivation of thrombin over other clotting factors
  • DOSE: Venous thromboembolism: 80 units/kg IV x 1, then 18 units/kg/hour ACS or Afib: 60 units/kg IV x 1, then 12 units/kg/hr 
  • EMERGENT INDICATION:  thromboembolism; ACS (enoxaparin preferred for NSTEMI) 
  • WARNINGS:  bleeding (protamine may be given for reversal), dosing errors, Preg C
  • Reference:ghoms Textbook Of Oral Medicine 

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