About:
¤Used in cardiac arrest setting or with symptomatic bradycardia.
¤Derived from an alkaloid extracted from deadly nightshade.
¤Was used to make women more attractive by dilating their pupils.
¤Deadly nightshade - Atropa belladonna.
Mode of action:
¤Competitive Muscarinic Ach blocker.
¤Blocks the action of acetyl choline.
Indications:
¤Symptomatic bradycardia.
¤Cardiac arrest setting.
¤Poisoning from organophosphates and nerve agents which increase Ach.
Interactions:
¤N/A
Contraindications:
¤Cardiac transplant - oversensitive use with great caution.
Side effects:
¤Reduced secretions, Delirium, Pupils dilate, Increased heart rate.
¤Relax smooth bowel, Urinary retention, Bronchodilation.
¤High dose - tachyarrhythmias e.g. VF,VT, SVT.
Atropine Dose:
¤Cardiac arrest up to 3 mg IV.
¤Bradycardia 500 mcg iv bolus repeated up to 3 mg IV.
¤Consider pacing if bradycardia induced hypotension persists.
Reference:Shanbhag Pharmacology 3rd edition
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