Less effective & less tolerated than PPI’s
Cimetidine:- Short duration of action; Enzyme inhibiror, increases plasma concentration of co-administrated drugs; Crosses BBB & produce CNS effects (confusion, headache, hallucinations); Increases plasma prolactin level, cause menstrual irregularities & galactorrhoea in women, gynaecomastia, oligospermia & impotence in men.
Other adverse effects:
Constipation, diarrhea, dry skin, tinnitus, nausea, vomiting etc.
Pharmacology 4th Ed: Tara V Shanbhag, Smita Shenoy