*Background* : Children with HIV are a special group with limited access to care and high prevalence of dental caries. Silver Diamine Fluoride (SDF) is approved universally for the management of asymptomatic carious lesions but research on the psychological impact of black staining is scarce.
*Aims* : Effect of silver diamine fluoride (SDF) application as an interim caries management on the child’s oral health-related quality of life of children with HIV over a period of 4 months until definitive care was provided.
*Settings and Design* : A pilot study conducted among children with HIV in a care home. It was a pilot trial to check the acceptability of SDF among these children.
*Methods and Material* : Forty-two children (12.3 ± 3.5 years) participated in this pilot study. Prevalence of caries (DMFT), candidiasis, gingival inflammation, and cervical lymphadenitis was evaluated. OHRQoL inventory (COHIP-SF) was completed by the students at baseline, immediately, 4 months after SDF application.
*Statistical Analysis Used:* One-way ANOVA with post hoc Tukey HSD test.
*Results and Conclusion* : Poor oral hygiene was universal and mean DMFT was 3.2 ± 2.5. OHRQoL was not significantly affected at baseline (26.2 ± 6.4), but immediately following SDF application, OHRQoL was significantly poor (48.7 ± 8.2), remained poor even after 4 months (42.6 ± 6.1). Emotional wellbeing was significantly impacted negatively following SDF application (p < 0.001); whereas oral health, functional wellbeing dimensions were not impacted. SDF should be used with caution among special children as the black discoloration of the teeth can cause emotional trauma and negatively impacting their OHRQoL while trying to improve the same.