Isonicotinic acid hydrazide (INH)
Highly effective and most widely used antitubercular agent.
First- line drug for treatment of TB. Used for chemo prophylaxis of TB.
- Hepatotoxicity : Common in alcoholics, elderly people, rapid acetylators. Symptoms like anorexia, nausea, vomiting, and jaundice are seen. Reversible on discontinuation of drug.
- PERIPHERAL NEURITIS : Competitively interferes with utilization of pyridoxine due to structural similarity. Peripheral neuritis is common in slow acetylators.
Pyridoxine 10mg/day + INH is given to reduce risk
3. Other side effects : Fever, skin rashes, arthralgia, anemia, GI disturbances, psychosis and rarely convulsions.
INH inhibits metabolism of pheytoin, carbamazepine, warfarin etc. ➡️ increases plasma levels of these drugs ➡️ may result in toxicity.
Pharmacology 4th Ed: Tara V Shanbhag, Smita Shenoy