Drugs of choice in Poisonings/Overdosage/Toxicities

Drug/Poison Antidote
Atropine (Belladona
poisoning)
Physostigmine
Benzodiazepins
(e.g. Diazepam)
Flumazenil
Beta-adrenoceptor antagonistsGlucagon, Adrenaline
Calcium channel blockersCalcium gluconate
CarbamateAtropine
CyanideSodium nitrite/ Amyl nitrite, oxygen, dicobalt edetate, sodium thiosulphate, hydroxocobaamine
Digoxin (Digitalis)Digoxin-specific antibody fragments (Digibind)
Ethylene glycol/ MethanolFomepizole, Ethanol
Fibrinolytics (e.g. Streptokinase)EACA (Epsilon amino caproic acid)
HeparinProtamine
Iron saltsDesferrioxamine
LeadSuccimer (DMSA 2,3-dimercaptosuccinic acid), disodium calcium edetate, Dimercaprol(BAL)
Mercury or ArsenicDimercaprol, d-Penicillamine
Opioids (e.g. Morphine)Naloxone
Oral Anticoagulants (e.g. Warfarin, rodenticides)Vitamin K, fresh frozen plasma
Organophosphorus- insecticides, nerve gasesAtropine, Pralidoxime
Paracetemol (Acetaminophen)N-acetylcysteine, Methionine
Copper (or Wilson’s disease)d-Penicillamine

ReferencesKD TripathiEssentials of Medical Pharmacology 7th Edition

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