Written by : Dr. Urusa I Inamdar


Paracetamol and acetaminophen are two official names of the same chemical compound derived from its chemical name : N-acetyl-para-aminophenol . It is an aniline derivative and the most extensively used over-the-counter and prescription analgesic worldwide . It has analgesic and anti-pyretic properties similar to non – steroidal antiinflammatory drugs (NSAIDS) but contrary to them , it does not possess any antiinflammatory properties .


It acts mainly in the CNS by inhibiting cyclo oxygenase ( COX-2 ) . It acts by preventing the oxidation of inactive COX to active COX and thereby preventing prostaglandins synthesis through an active metabolite influencing cannabinoid receptors .


It is rapidly absorbed from the gastrointestinal tract . The peak plasma concentrations are reached in about 2-3 hrs after rectal administration and reaches total serum concentrations of 5-20 micro g/ml . It is primarily metabolized in the liver by conjugation to gluconide and sulfate .


  • Analgesic
  • Antipyretic


  • Alcoholism
  • Hepatic disease
  • Viral hepatitis
  • Hypertension

Drug interactions:

Paracetamol interacts with enzyme inducing substances , such as isoniazid , carbamazepine , phenytoin or barbiturates , as well as chronic alcohol excess which increases N-acetyl-p-benzoquinone imine production and the risk of toxicity .

Adverse reactions:

  • Allegic dermatitis
  • Thrombocytopenia
  • Agranulocytosis
  • Hepatic necrosis

Dosage and administration:

As directed by the physician


Each suppository contains Paracetamol 125 mg


  • CIMS – prescribers handbook
  • Kulkarni R et al. Indian J Pharmacol 2007
  • Cullen S et al Arch Dis Child
  • Roberts E et al. Ann Rheum Dis. 2016

One thought on “PARACETAMOL

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